Amibegron

Amibegron is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron has anxiolytic and antidepressant activity.

Product Specifications

CAS Number

[121524-08-1]

Product Name Alternative

SR-58611

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/amibegron.html

Solubility

10 mM in DMSO

Smiles

O[C@H](C1=CC(Cl)=CC=C1)CN[C@@H]2CC3=CC(OCC(OCC)=O)=CC=C3CC2

Molecular Formula

C22H26ClNO4

Molecular Weight

403.90

References & Citations

[1]Bianchetti A, et al. In vitro inhibition of intestinal motility by phenylethanolaminotetralines: evidence of atypical beta-adrenoceptors in rat colon. Br J Pharmacol. 1990 Aug;100 (4) :831-9.|[2]Simiand J, et al. Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors. Eur J Pharmacol. 1992 Aug 25;219 (2) :193-201.|[3]Claustre Y, et al. Effects of the beta3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience. 2008 Oct 2;156 (2) :353-64.