Vinzolidine

Vinzolidine is a semisynthetic derivative of the catharanthus alkaloid. Vinzolidine exerts its cytotoxic effect on tumor cells by interfering with microtubulin polymerization, thereby inhibiting cell division. Vinzolidine can be utilized in research to investigate synergistic effects when combined with other chemotherapeutic agents or biologic therapies, as well as to study cancer cells' tolerance or resistance to these treatments, and to explore approaches to overcome such obstacles[1].

Product Specifications

CAS Number

[67699-40-5]

Product Name Alternative

LY 104208

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vinzolidine.html

Smiles

CC[C@]1(O)C[C@H]2C[C@@](C3=C(OC)C=C4C([C@]56CCN7[C@H]5[C@@]([C@@H](OC(C)=O)[C@]8(C(N(CCCl)C(O8)=O)=O)[C@@H]6N4C)(CC)C=CC7)=C3)(C(OC)=O)C9=C(C%10=CC=CC=C%10N9)CCN(C1)C2

Molecular Formula

C48H58ClN5O9

Molecular Weight

884.46

References & Citations

[1]Aapro M S, et al. Interactions of human leukocyte interferon with vinca alkaloids and other chemotherapeutic agents against human tumors in clonogenic assay[J]. Cancer Chemotherapy and Pharmacology, 1983, 10: 161-166.