Pan-KRAS-IN-7
Pan-KRAS-IN-7 (Compound 25) is an inhibitor for in human tumor mutated genes KRAS, which inhibits proliferation of KRAS mutated cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with IC50 of 0.35 and 0.51 nM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-7.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1N(CC#CC2=C[C@]([C@]3=C(CC(C)(C)COC4=O)C5=CC(C6=CSC(C[C@H](NC([C@H]7[C@H](C)[C@@H]7C)=O)C(N8CCC[C@@H]4N8)=O)=N6)=CC=C5N3CC)=C([C@H](C)OC)N=C2)CCOC1
Molecular Formula
C48H61N7O7S
Molecular Weight
880.11
References & Citations
[1]Chen YF, et al., Pan-kras inhibitor compound. WO2024060966A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6460166-01 0.1 mL
VAC14 (Protein VAC14 Homolog, Tax1-Binding Protein 2, VAC14, TAX1BP2, TRX) (AP)
Ask
View Details MBS6460166-02 5x 0.1 mL
VAC14 (Protein VAC14 Homolog, Tax1-Binding Protein 2, VAC14, TAX1BP2, TRX) (AP)
Ask
View Details