BDM88855 (hydrochloride)
BDM88855 hydrochloride is an allosteric inhibitor for the homolog AcrB protein. BDM88855 hydrochloride can boost the antibacterial effect of a panel of antibiotics (eg: Oxacillin , Linezolid (HY-10394), Novobiocin (HY-B0425), etc.) on wild-type E. coli[1][2].
Product Specifications
CAS Number
2892824-26-7
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bdm88855-hydrochloride.html
Smiles
ClC1=C(N2CCNCC2)N=C(C=CC=C3)C3=C1.Cl
Molecular Formula
C13H15Cl2N3
Molecular Weight
284.18
References & Citations
[1]Plé C, et al. Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps. Nat Commun. 2022 Jan 10;13 (1) :115. |[2]Bera A, et al. Exploring transmembrane allostery in the MexB: DB08385 variant as a promising inhibitor-like candidate against Pseudomonas aeruginosa antibiotic resistance: a computational study. Phys
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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