GSK-3β inhibitor 2

GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease[1].

Product Specifications

CAS Number

[1702428-31-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk-3β-inhibitor-2.html

Purity

97.68

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(C1=C(OC)N=C(C2=CC(NC(C3CC3)=O)=NC=C2)S1)N

Molecular Formula

C14H14N4O3S

Molecular Weight

318.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Sivaprakasam P, et al. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett. 2015 May 1;25 (9) :1856-63.