CM-444
CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM) . CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models[1].
Product Specifications
UNSPSC
12352005
Target
DNA Methyltransferase; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cm-444.html
Smiles
O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO
Molecular Formula
C27H30N6O5
Molecular Weight
518.56
References & Citations
[1]San José-Enériz E, et al., Epigenetic-based differentiation therapy for Acute Myeloid Leukemia. Nat Commun. 2024 Jul 2;15 (1) :5570.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT1; DNMT3; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Ashbya gossypii Spindle pole body component KRE28 (KRE28)
Recombinant Ashbya gossypii Spindle pole body component KRE28 (KRE28)
Recombinant Ashbya gossypii Spindle pole body component KRE28 (KRE28)
Recombinant Ashbya gossypii Spindle pole body component KRE28 (KRE28)
Recombinant Ashbya gossypii Spindle pole body component KRE28 (KRE28)