AR Degrader-1
AR Degrader-1 (Compound ML 2-9) is a molecular glue androgen receptor (AR) monovalent degrader. AR Degrader-1 degrades AR through DCAF16 (E3 ligase) without obvious cytotoxicity in LNCaP prostate cancer cells[1].
Product Specifications
UNSPSC
12352005
Target
Androgen Receptor; E1/E2/E3 Enzyme; Molecular Glues
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar-degrader-1.html
Smiles
O=C(C1=NN=C(N2CCN(S(=O)(C=C)=O)CC2)C=C1)N[C@H]3CC[C@H](OC4=CC=C(C#N)C(Cl)=C4)CC3
Molecular Formula
C24H27ClN6O4S
Molecular Weight
531.03
References & Citations
[1]Melissa Lim, et al. DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders. ACS Central Science. DOI: 10.1021/acscentsci.4c00286
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC471073-100 1x 100 µL
HLA-Aw32 & HLA-A25 (MHC I) (CATA-1), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470304-500 1x 500 µL
CD106 / VCAM1 (B-K9), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470630-500 1x 500 µL
Mucin 1 / EMA / Episialin / CD227 (VU-2G7), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details