JD-02
JD-02 is a novel Hsp90 inhibitor. JD-02 can induce autophagy and apoptosis. JD-02 increses the level of reactive oxygen species[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Autophagy; HSP
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jd-02.html
Solubility
10 mM in DMSO
Smiles
CC1=NN(C2=CC=C(C(N)=O)C(N[C@@H]3CC[C@@H](O)CC3)=C2)C4=C1/C(CC(C)(C)C4)=N/N
Molecular Formula
C23H32N6O2
Molecular Weight
424.54
References & Citations
[1]Lan N, et al. JD-02, a novel Hsp90 inhibitor, induces ROS/SRC axis-dependent cytoprotective autophagy in colorectal cancer cells. Mol Carcinog. Published online February 27, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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