DL-Allylglycine

DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine significantly increases mouse brain ornithine decarboxylase (ODC) activity and decreases S-adenosyl-L-methionine decarboxylase (SAM-DC) activity. DL-Allylglycine causes a marked decrease in brain GABA concentration. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures[1][2].

Product Specifications

CAS Number

[7685-44-1]

Product Name Alternative

2-Aminopent-4-enoic acid

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Amino Acid Decarboxylase

Type

Peptides

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dl-allylglycine.html

Purity

98.0

Solubility

H2O : 5.41 mg/mL (ultrasonic)

Smiles

C=CCC(N)C(O)=O

Molecular Formula

C5H9NO2

Molecular Weight

115.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Pajunen AE, et al. The effect of DL-allylglycine on polyamine and GABA metabolism in mouse brain. J Neurochem. 1979 May;32 (5) :1401-8. |[2]Wada Y, et al. Effects of allylglycine on photosensitivity in the lateral geniculate-kindled cat. Exp Neurol. 1986 Oct;94 (1) :228-36.