Epi-galantamine

Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii) . Epi-galantamine inhibits AChE with an EC50 of 45.7 μM[1][2][3].

Product Specifications

CAS Number

[1668-85-5]

UNSPSC

12352005

Hazard Statement

H301-H315-H317-H331

Target

Cholinesterase (ChE)

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/epi-galantamine.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1C=C[C@@]23CCN(C)CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24

Molecular Formula

C17H21NO3

Molecular Weight

287.35

Precautions

P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Thomsen T, et al. Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans. Eur J Clin Pharmacol. 1990;39 (6) :603-5.|[2]Berkov S, et al. Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts. Phytochem Anal. 2008 Sep-Oct;19 (5) :411-9.|[3]Maláková J, et al. High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853 (1-2) :265-74.