GSK9027

GSK9027, as a non-steroidal glucocorticoid receptor (GR) agonist, behaves as a partial agonist on the 2xglucocorticoid response element (GRE) reporter system, and achieves intrinsic activities relative to dexamethasone[1][2].

Product Specifications

CAS Number

[1229096-88-1]

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/gsk9027.html

Purity

98.85

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=S(CC1=CC=CC=C1)(NC2=CC=C(C3=CC4=C(N(C5=CC=C(F)C=C5)N=C4)C=C3)C(C(F)(F)F)=C2)=O

Molecular Formula

C27H19F4N3O2S

Molecular Weight

525.52

References & Citations

[1] Rider CF, et al. Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands. PLoS ONE. 2015; 10 (1) : e0116773.|[2]Rider, C. F., et al. TNF±-Induced Glucocorticoid Resistance: Inhibition Of Inflammatory Signalling And The Effect On Full And Partial GR Agonists. 2012