HSP90-IN-31
Product Specifications
UNSPSC Description
HSP90-IN-31 (compound Be01) causes reduction of CD80 and CD86 expression on dendritic cells (DCs). HSP90-IN-31 decreases the production of pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β) in BMDC and peritoneal macrophages stimulated by LPS (HY-D1056). Under the delayed-type hypersensitivity (DTH) mice model, HSP90-IN-31 reduces ear swelling and pro-inflammatory cytokines in the spleen[1].
Target Antigen
Interleukin Related; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hsp90-in-31.html
Smiles
CC(C)C1=C(O)C=C(O)C(C(N(C)CC2=CC=C(C(NCCC)=O)C=C2)=O)=C1
Molecular Weight
384.47
References & Citations
[1]Hyun Bo Sim, et al. Development of Hsp90 inhibitor to regulate cytokine storms in excessive delayed- and acute inflammation. Int Immunopharmacol. 2024 Aug 20:137:112470.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161833/HSP90-IN-31-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161833/
Clinical Information
No Development Reported
CAS Number
2117645-10-8
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