DCN1-IN-2
DCN1-IN-2 is a DCN1 inhibitor with an IC50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3[1].
Product Specifications
CAS Number
2543578-57-8
UNSPSC
12352005
Target
TGF-beta/Smad
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dcn1-in-2.html
Smiles
O=C(CCN1C(NN=C1C2=CC=C(Cl)C=C2)=S)NC3=CC=CC(C(F)(F)F)=C3
Molecular Formula
C18H14ClF3N4OS
Molecular Weight
426.84
References & Citations
[1]He ZX, et al. Discovery of 1,2,4-Triazole-3-thione Derivatives as Potent and Selective DCN1 Inhibitors for Pathological Cardiac Fibrosis and Remodeling. J Med Chem. 2024 Aug 19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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