DCN1-IN-2

DCN1-IN-2 is a DCN1 inhibitor with an IC50 value of 2.96 nM. DCN1-IN-2 can alleviate Ang II/TGFβ-induced activation of cardiac fibroblasts. DCN1-IN-2 can reduce ISO-induced cardiac fibrosis and remodeling in mice by selectively inhibiting cullin 3[1].

Product Specifications

CAS Number

[2543578-57-8]

UNSPSC

12352005

Target

TGF-beta/Smad

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dcn1-in-2.html

Smiles

O=C(CCN1C(NN=C1C2=CC=C(Cl)C=C2)=S)NC3=CC=CC(C(F)(F)F)=C3

Molecular Formula

C18H14ClF3N4OS

Molecular Weight

426.84

References & Citations

[1]He ZX, et al. Discovery of 1,2,4-Triazole-3-thione Derivatives as Potent and Selective DCN1 Inhibitors for Pathological Cardiac Fibrosis and Remodeling. J Med Chem. 2024 Aug 19.