Tubulin polymerization-IN-63

Tubulin polymerization-IN-63 (compound 6) is a tubulin polymerization inhibitor. The IC50 value of Tubulin polymerization-IN-63 for MES-SA cells is 0.29 μM. Tubulin polymerization-IN-63 can be used in cancer research[1].

Product Specifications

CAS Number

[3040385-73-4]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-63.html

Smiles

Cl[Cu]12([N]3(C4)CCOCC3)[N](N=C(NC5=CC(C)=C(O)C(C)=C5)S2)=CC6=CC=CC4=[N]61

Molecular Formula

C20H24ClCuN5O2S

Molecular Weight

497.50

References & Citations

[1]Milunovic MNM, et al. Copper (II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters. J Med Chem. 2024 Jun 13;67 (11) :9069-9090.