Pirepemat
Pirepemat (IRL752) is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat (IRL752) is used for the study of Parkinson's disease[1][2]. IRL752 is a selective enhancer of cortical dopamine, acetylcholine and norepinephrine[3].
Product Specifications
CAS Number
1227638-29-0
Product Name Alternative
IRL752
UNSPSC
12352005
Target
Adrenergic Receptor; Cholinesterase (ChE) ; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pirepemat.html
Solubility
10 mM in DMSO
Smiles
CO[C@]1(C(C=CC=C2F)=C2F)CCNC1
Molecular Formula
C11H13F2NO
Molecular Weight
213.22
References & Citations
[1]Ipsen and IRLAB Enter Exclusive Worldwide Licensing Agreement Aimed to Improve the Lives of People Living with Parkinson's Disease.|[2]S Hjorth, et al. (3 S) -3- (2,3-difluorophenyl) -3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374 (3) :404-419.|[3]Systematic review of pharmacological interventions for people with Lewy body dementia
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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