(2S) -2'-Methoxykurarinone

(2S) -2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S) -2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S) -2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells[1][2].

Product Specifications

CAS Number

[270249-38-2]

Product Name Alternative

2'-O-Methylkurarinone

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

RANKL/RANK

Type

Natural Products

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/2s-2-methoxykurarinone.html

Purity

98.86

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C[C@@H](C2=CC=C(O)C=C2OC)OC3=C(C[C@H](C(C)=C)C/C=C(C)\C)C(O)=CC(OC)=C13

Molecular Formula

C27H32O6

Molecular Weight

452.54

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kim JY, et al. (2S) -2'-Methoxykurarinone inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. Biol Pharm Bull. 2014;37 (2) :255-61.|[2]Kang TH, et al. Cytotoxic lavandulyl flavanones from Sophora flavescens. J Nat Prod. 2000 May;63 (5) :680-1.