SM-102

SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs) . SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines[1][2].

Product Specifications

CAS Number

[2089251-47-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sm-102.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 100 mg/mL

Smiles

O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCO)CCCCCC(OCCCCCCCCCCC)=O

Molecular Formula

C44H87NO5

Molecular Weight

710.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Escalona-Rayo O, et al. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy. Biomed Pharmacother. 2023 Sep;165:115065.|[2]Cho HY, et al. Effective Perturbations on the Amplitude and Hysteresis of Erg-Mediated Potassium Current Caused by 1-Octylnonyl 8-[ (2-hydroxyethyl) [6-oxo-6 (undecyloxy) hexyl]amino]-octanoate (SM-102), a Cationic Lipid. Biomedicines. 2021 Oct 1;9 (10) :1367. |[3]Mashima R, et al. Lipid Nanoparticles: A Novel Gene Delivery Technique for Clinical Application. Curr Issues Mol Biol. 2022 Oct 19;44 (10) :5013-5027.|[4]McKenzie RE, et al. mRNA Synthesis and Encapsulation in Ionizable Lipid Nanoparticles. Curr Protoc. 2023 Sep;3 (9) :e898.