Fanapanel (hydrate)
Product Specifications
UNSPSC Description
Fanapanel hydrate (ZK200775 hydrate) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively.
Target Antigen
iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ZK200775-hydrate.html
Solubility
DMSO : 5 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(N1CP(O)(O)=O)C(NC(C1=C2)=CC(C(F)(F)F)=C2N3CCOCC3)=O.[H]O[H]
Molecular Weight
427.27
References & Citations
[1]Turski L, et al. ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10960-5.|[2]Kosowski AR, et al. Nicotine-induced dopamine release in the nucleus accumbens is inhibited by the novel AMPA antagonist ZK200775 and the NMDA antagonist CGP39551. Psychopharmacology (Berl). 2004 Aug;175(1):114-23.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15069A/Fanapanel-hydrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15069A/Fanapanel-hydrate-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1255517-78-2
Available Sizes
Curated Selection
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