Clorgyline hydrochloride

Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A) . Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3].

Product Specifications

CAS Number

[17780-75-5]

UNSPSC

12352005

Hazard Statement

H301

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Clorgiline-hydrochloride.html

Purity

99.92

Solubility

DMSO : 87.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

C#CCN(CCCOC1=CC=C(Cl)C=C1Cl)C.[H]Cl

Molecular Formula

C13H16Cl3NO

Molecular Weight

308.63

Precautions

H301

References & Citations

[1]Murphy DL, et al. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline) . Journal of neural transmission. Supplementum 52: 39-48.|[2]Guillem K, et al. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats[J]. Eur J Neurosci. 2006 Dec;24 (12) :3532-40. |[3]Tyce GM, et al. Conjugated dopamine in superfusates of slices of rat striatum[J]. J Neurochem. 1982 Nov;39 (5) :1333-9.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Biochem Biophys Res Commun. 2022 May 28;606:135-141.|Cell Rep. 2022 Dec 13;41 (11) :111827.|FASEB J. 2021 Jun;35 (6) :e21652.|Immunomedicine. 2022 Dec;2 (2) :e1041.|J Immunother Cancer. 2025 Mar 22;13 (3) :e010555.|Sci Total Environ. 2023 Dec 15:904:166688.|Chembiochem. 2025 Oct 28:e202500462.