Amitifadine

Amitifadine (DOV-21947; EB-1010) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC50s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

Product Specifications

CAS Number

[410074-73-6]

Product Name Alternative

DOV-21947; EB-1010

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dopamine Receptor; Dopamine Transporter; Serotonin Transporter

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/amitifadine.html

Smiles

ClC1=C(Cl)C=CC([C@]23[C@](CNC3)([H])C2)=C1

Molecular Formula

C11H11Cl2N

Molecular Weight

228.12

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Skolnick P1, et al. Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461 (2-3) :99-104.|[2]Levin ED, et al. Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol. 2015 Jun 20;764:30-37.