KRAS inhibitor-37
Product Specifications
UNSPSC Description
KRAS inhibitor-37 (compound 2) is a potent KRAS inhibitor with KDs of 0.004 nM, 0.041 nM, 0.019 nM and 0.144 nM for KRAS wild type, KRAS G12D, KRAS G12C and KRAS G12V by SPR binding assay, respectively. KRAS inhibitor-37 inhibits cell proliferation with IC50s of [1].
Target Antigen
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-inhibitor-37.html
Smiles
C=C1CN2CCC[C@]2(C1)COC3=NC4=C5C(OC[C@@H]6COCCCN6C5=N3)=NC(C7=C8C=NNC8=CC(Cl)=C7C9CC9)=C4F
Molecular Weight
618.10
References & Citations
[1]Benjamin Joseph Burke, et al. Pyrido[4,3-d]pyrimidine compounds. WO2024209339A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169311/KRAS-inhibitor-37-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169311/
Clinical Information
No Development Reported
CAS Number
3058573-95-5
Curated Selection
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