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KRAS inhibitor-37

KRAS inhibitor-37 (compound 2) is a potent KRAS inhibitor with KDs of 0.004 nM, 0.041 nM, 0.019 nM and 0.144 nM for KRAS wild type, KRAS G12D, KRAS G12C and KRAS G12V by SPR binding assay, respectively. KRAS inhibitor-37 inhibits cell proliferation with IC50s of [1].

Product Specifications

CAS Number

[3058573-95-5]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kras-inhibitor-37.html

Smiles

C=C1CN2CCC[C@]2(C1)COC3=NC4=C5C(OC[C@@H]6COCCCN6C5=N3)=NC(C7=C8C=NNC8=CC(Cl)=C7C9CC9)=C4F

Molecular Formula

C32H33ClFN7O3

Molecular Weight

618.10

References & Citations

[1]Benjamin Joseph Burke, et al. Pyrido[4,3-d]pyrimidine compounds. WO2024209339A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

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