α-Bungarotoxin

α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs) . α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM[1][2].

Product Specifications

CAS Number

[11032-79-4]

UNSPSC

12352209

Hazard Statement

H302, H312, H332

Target

NAChR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-bungarotoxin.html

Purity

99.0

Solubility

H2O : ≥ 50 mg/mL

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(NC4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC5=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@H]5CC6=CC=CC=C6)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC7=O)C(N[C@@H](CC8=CNC=N8)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N9[C@@H](CCC9)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N%10[C@@H](CCC%10)C(N[C@@H](CC%11=CNC=N%11)C(N%12[C@@H](CCC%12)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N%13[C@@H](CCC%13)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%14=O)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@H]%14CCCCN)=O)=O)=O)=O)=O)NC%15=O)C(N%16[C@@H](CCC%16)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N%17[C@@H](CCC%17)C(N[C@@H](CC%18=CC=C(C=C%18)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H]%15[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC4=O)C(N%19[C@@H](CCC%19)C(N%20[C@@H](CCC%20)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@H]7CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N

Molecular Formula

C338H529N97O105S11

Molecular Weight

7984.12

Precautions

H302, H312, H332

References & Citations

[1]Hannan S, et al. Snake neurotoxin α-bungarotoxin is an antagonist at native GABA (A) receptors. Neuropharmacology. 2015;93:28-40.|[2]López MG, et al. Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers. Proc Natl Acad Sci U S A. 1998;95 (24) :14184-14189.|[3]Balass M, et al. The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: analysis using a phage-epitope library. Proc Natl Acad Sci U S A. 1997;94 (12) :6054-6058.