Human 5-Hydroxytryptamine 2B Receptor

<strong>Human 5-Hydroxytryptamine 2B Receptor</strong>_x000D_ <strong>Catalog number:</strong> B2016513_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 25 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> N/A_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> N/A_x000D_ <strong>Keywords:</strong> 5-HT-2B_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Reid TE, Kumar K, Wang XS. Predictive in silico studies of human 5-hydroxytryptamine receptor subtype 2B (5-HT2B) and valvular heart disease Curr Top Med Chem. 2013;13(11):1353-62._x000D_ 2: McCorvy JD, Roth BL. Structure and function of serotonin G protein-coupled receptors Pharmacol Ther. 2015 Jun;150:129-42._x000D_ 3: David DJ, Gardier AM. [The pharmacological basis of the serotonin system: Application to antidepressant response] Encephale. 2016 Jun;42(3):255-63._x000D_ 4: Russell A, Banes A, Berlin H, Fink GD, Watts SW. 5-Hydroxytryptamine(2B) receptor function is enhanced in the N(omega)-nitro-L-arginine hypertensive rat J Pharmacol Exp Ther. 2002 Oct;303(1):179-87._x000D_ 5: Bennet H, Mollet IG, Balhuizen A, Medina A, Nagorny C, Bagge A, Fadista J, Ottosson-Laakso E, Vikman P, Dekker-Nitert M, Eliasson L, Wierup N, Artner I, Fex M. Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans Diabetologia. 2016 Apr;59(4):744-54._x000D_ 6: Bender AM, Parr LC, Livingston WB, Lindsley CW, Merryman WD. 2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery J Med Chem. 2023 Aug 24;66(16):11027-11039._x000D_ 7: Löfdahl A, Tornling G, Wigén J, Larsson-Callerfelt AK, Wenglén C, Westergren-Thorsson G. Pathological Insight into 5-HT(2B) Receptor Activation in Fibrosing Interstitial Lung Diseases Int J Mol Sci. 2020 Dec 28;22(1):225._x000D_ 8: Wenglén C, Demirel I, Eremo AG, Grenegård M, Paramel GV. Targeting serotonin receptor 2B inhibits TGFβ induced differentiation of human vascular smooth muscle cells Eur J Pharmacol. 2023 Apr 5;944:175570._x000D_ 9: Peng L, Huang J. Astrocytic 5-HT(2B) receptor as in vitro and in vivo target of SSRIs Recent Pat CNS Drug Discov. 2012 Dec;7(3):243-53._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/30127358">10: McCorvy JD, Wacker D, Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, Roth BL. Structural determinants of 5-HT(2B) receptor activation and biased agonism Nat Struct Mol Biol. 2018 Sep;25(9):787-796. </a>_x000D_ _x000D_ <strong>Products Related to Human 5-Hydroxytryptamine 2B Receptor can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>