NSC727447
NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively[1].
Product Specifications
CAS Number
40106-12-5
UNSPSC
12352005
Hazard Statement
H302
Target
DNA/RNA Synthesis; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nsc727447.html
Purity
95.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N)SC2=C1CCCCC2)N
Molecular Formula
C10H14N2OS
Molecular Weight
210.30
Precautions
H302
References & Citations
[1]Michaela Wendeler, et al. Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity. ACS Chem Biol. 2008 Oct 17;3 (10) :635-44.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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