NSC727447

NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively[1].

Product Specifications

CAS Number

[40106-12-5]

UNSPSC

12352005

Hazard Statement

H302

Target

DNA/RNA Synthesis; HIV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/nsc727447.html

Purity

95.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(N)SC2=C1CCCCC2)N

Molecular Formula

C10H14N2OS

Molecular Weight

210.30

Precautions

H302

References & Citations

[1]Michaela Wendeler, et al. Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity. ACS Chem Biol. 2008 Oct 17;3 (10) :635-44.