OICR-8268-acrylic acid
OICR-8268-acrylic acid is a ligand for E3 ubiquitin ligase. OICR-8268-acrylic acid can be connected to the ligand for protein by a linker to form OICR41114. OICR41114 can be used in anti-cancer research[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oicr-8268-acrylic-acid.html
Smiles
O=C(O)/C=C/C1=C(C(C(N[C@H](C2=CC=C(C(Cl)=C2)F)CC(N)=O)=O)=CN1)C3=C(C=C(C=C3)Cl)F
Molecular Formula
C23H17Cl2F2N3O4
Molecular Weight
508.30
References & Citations
[1]Mabanglo MF, et al. Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity. Nat Commun. 2024 Nov 23;15 (1) :10165.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
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