Syk Inhibitor II

Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect[1].

Product Specifications

CAS Number

[726695-51-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

5-HT Receptor; Syk

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/syk-inhibitor-ii.html

Purity

98.15

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(C1=CN=C(NCCN)N=C1NC2=CC=CC(C(F)(F)F)=C2)N

Molecular Formula

C14H15F3N6O

Molecular Weight

340.30

Precautions

H315, H319, H335

References & Citations

[1]Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13 (16) :4936-51.