Ac-DMQD-AMC
Ac-DMQD-AMC is an inhibitor of caspase-3. Ac-DMQD-AMC is an aromatic amine using aminium-based coupling reagent HATU in the presence of 2,4,6-trimethylpyridine (TMP) [1].
Product Specifications
CAS Number
355137-38-1
UNSPSC
12352209
Target
Caspase
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ac-dmqd-amc.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CC=C(C=C1O2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)CC(O)=O)=O)CCSC)=O)CCC(N)=O)=O)CC(O)=O)=O)=CC2=O
Molecular Formula
C30H38N6O12S
Molecular Weight
706.72
References & Citations
[1]Przemysław Reszka, et al. Control of aspartate epimerization during the coupling of caspase specific tetrapeptides with aromatic amines by using N-[[ (dimethylamino) -1H-1,2,3-triazolo[4,5-b]-pyridin-1-yl]methylene]-N-methylmethanaminium hexafluorophosphate N-oxide (HATU) as a coupling reagent. Tetrahedron: Asymmetry. 2008, 19, 1.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Caspase 3
Frequently Asked Questions
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