DNMT1-IN-3
DNMT1-IN-3 (compound 7t-S) is an effective DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 value of 0.777 μM and a KD value of 0.183 μM. DNMT1-IN-3 can bind to the methyl donor S-adenosyl-l-methionine (SAM) site in DNMT1. DNMT1-IN-3 can inhibit cell proliferation in K562 cells by inducing cells apoptosis and arresting cell cycle at G0 / G1 phase, which has the potential to be used for the research of hematologic tumor[1].
Product Specifications
CAS Number
3025012-68-1
UNSPSC
12352005
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dnmt1-in-3.html
Smiles
O=C(O)[C@@H](N(C(C1=C2C=CC=C1)=O)C2=O)CN3C4=C(C5=C3C=CC(Cl)=C5)C=C(Cl)C=C4Cl
Molecular Formula
C23H13Cl3N2O4
Molecular Weight
487.72
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT1
Frequently Asked Questions
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