DNMT1-IN-3

DNMT1-IN-3 (compound 7t-S) is an effective DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 value of 0.777 μM and a KD value of 0.183 μM. DNMT1-IN-3 can bind to the methyl donor S-adenosyl-l-methionine (SAM) site in DNMT1. DNMT1-IN-3 can inhibit cell proliferation in K562 cells by inducing cells apoptosis and arresting cell cycle at G0 / G1 phase, which has the potential to be used for the research of hematologic tumor[1].

Product Specifications

CAS Number

[3025012-68-1]

UNSPSC

12352005

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dnmt1-in-3.html

Smiles

O=C(O)[C@@H](N(C(C1=C2C=CC=C1)=O)C2=O)CN3C4=C(C5=C3C=CC(Cl)=C5)C=C(Cl)C=C4Cl

Molecular Formula

C23H13Cl3N2O4

Molecular Weight

487.72

References & Citations

[1]Liu J, et al. Identification of 3- (9H-carbazol-9-yl) -2- (1,3-dioxoisoindolin-2-yl) propanoic acids as promising DNMT1 inhibitors. Eur J Med Chem. Published online May 27, 2024.