Lenvatinib N-oxide

Lenvatinib N-Oxide (Lenvatinib impurity 10) is the impurity of Lenvatinib (HY-10981) . Lenvatinib (E7080) is an orally active, multi-targeted tyrosine kinase inhibitor[1].

Product Specifications

CAS Number

[1788901-86-9]

Product Name Alternative

Lenvatinib impurity 10

UNSPSC

12352005

Hazard Statement

H361-H373

Target

VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lenvatinib-n-oxide.html

Smiles

O=C(C1=CC2=C(OC3=CC=C(NC(NC4CC4)=O)C(Cl)=C3)C=C[N+]([O-])=C2C=C1OC)N

Molecular Formula

C21H19ClN4O5

Molecular Weight

442.85

Precautions

P260-P280-P405-P501

References & Citations

[1]Kudo M, et al. Lenvatinib versus Bay 43-9006 in first-line treatment of patients with unresectable hepatocellularcarcinoma: a randomised phase 3 non-inferiority trial. Lancet. 2018 Mar 24;391 (10126) :1163-1173.