L67
L67 (DNA Ligase Inhibitor) is a competitive DNA ligase inhibitor that effectively inhibits DNA ligases I/III (both IC50 are 10 μM) . L67 can cause nuclear DNA damage by reducing levels of mitochondrial DNA and increasing levels of mitochondrially-generated ROS. L67 also activates the Caspase 1-dependent apoptosis pathway in cancer cells, can be used in cancer research[1][2].
Product Specifications
CAS Number
325970-71-6
Product Name Alternative
DNA Ligase Inhibitor
UNSPSC
12352005
Hazard Statement
H302, H361, H372, H410
Target
Apoptosis; Caspase; DNA/RNA Synthesis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/L67.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
BrC1=CC(NCC(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)=CC(Br)=C1C
Molecular Formula
C16H14Br2N4O4
Molecular Weight
486.11
Precautions
H302, H361, H372, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1
Available Sizes
Frequently Asked Questions
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