IGF-I Receptor β (phospho-Tyr980) rabbit pAb
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],
Product Specifications
Background
Product Name Alternative
UniProt
P08069
Swiss Prot
P08069
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized phosho peptide around human IGF-I Receptor β (Tyr980)
Target
IGF-1R
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:1000-2000
Buffer
-20°C/1 year
Molecular Weight
pro: 155kD, recetor beta: 95kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
Pro: 155kD, recetor beta: 95kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Other Product Names
Gene ID (Human)
3480
Available Sizes
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