UM4118
Product Specifications
UNSPSC Description
UM4118 is a copper ionophore that can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research[1].
Target Antigen
Cuproptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/um4118.html
Solubility
DMSO : 116.67 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=NC=CC=C1)NC2=CC=CC3=CC=CN=C32
Molecular Weight
249.27
References & Citations
[1]Moison C, et al. <i>SF3B1</i> mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia. Sci Adv. 2024;10(12):eadl4018.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162386/UM4118-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162386/UM4118-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
324530-92-9
Available Sizes
Curated Selection
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