UM4118

UM4118 is a copper ionophore that can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research[1].

Product Specifications

CAS Number

[324530-92-9]

UNSPSC

12352005

Target

Cuproptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/um4118.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 116.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=NC=CC=C1)NC2=CC=CC3=CC=CN=C32

Molecular Formula

C15H11N3O

Molecular Weight

249.27

References & Citations

SF3B1

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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