UM4118
UM4118 is a copper ionophore that can initiate a mitochondrial-based noncanonical form of cell death known as cuproptosis. UM4118 exhibits high sensitivity in SF3B1-mutated and adverse risk acute myeloid leukemia (AML), and can be used for AML research[1].
Product Specifications
CAS Number
[324530-92-9]
UNSPSC
12352005
Target
Cuproptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/um4118.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 116.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC=CC=C1)NC2=CC=CC3=CC=CN=C32
Molecular Formula
C15H11N3O
Molecular Weight
249.27
References & Citations
SF3B1
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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