CDK-IN-14
Product Specifications
UNSPSC Description
CDK-IN-14 (B34) is a CDK2 inhibitor (IC50=0.097 μM) with anti-hepatocellular carcinoma activity. CDK-IN-14 blocks the cell cycle of HepG-2 cancer cells through a caspase-mediated mechanism and induces apoptosis[1].
Target Antigen
Apoptosis; Caspase; CDK
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk-in-14-1.html
Smiles
COC1=C(OC)C=C(N=C(NC2=CC=C(OCC3=CC(F)=CC=C3)C(Cl)=C2)N=C4NCC5=CC=CC=C5)C4=C1
Molecular Weight
545.00
References & Citations
[1]Venkatesan G, et al. Design, synthesis, molecular docking, and evaluation of sulfonyl quinazoline analogues as promising liver cancer drugs[J]. Bioorganic Chemistry, 2024: 107777.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168067/CDK-IN-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168067/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
11770080-AAT 100 Tests
IFluor® 546 Anti-non-human primates/ human CD177 Antibody *MEM-166*
Ask
View Details 
