Embelin
Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells[1][2][3].
Product Specifications
CAS Number
550-24-3
Product Name Alternative
Embelic acid; Emberine; NSC 91874
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; IAP; NF-κB
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/embelin.html
Purity
99.01
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O
Molecular Formula
C17H26O4
Molecular Weight
294.39
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
XIAP
Available Sizes
Frequently Asked Questions
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