Embelin

Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells[1][2][3].

Product Specifications

CAS Number

[550-24-3]

Product Name Alternative

Embelic acid; Emberine; NSC 91874

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; IAP; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; Autophagy; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/embelin.html

Purity

99.01

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O

Molecular Formula

C17H26O4

Molecular Weight

294.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Nikolovska-Coleska Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem. 2004;47 (10) :2430-2440.|[2]Ahn KS, et al. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol. 2007;71 (1) :209-219.|[3]Lee YJ, et al. XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells. Environ Toxicol. 2017;32 (11) :2371-2378.