Phosphatidylinositol-1,2-dioctanoyl (sodium)
Phosphatidylinositol-1,2-dioctanoyl sodium significantly inhibits transmembrane P-gp transport in a reproducible, cell line-independent, and substrate-independent manner. Phosphatidylinositol-1,2-dioctanoyl sodium plays an important role in signal transduction and cell movement[1].
Product Specifications
CAS Number
899827-36-2
Product Name Alternative
PtdIns- (1,2-dioctanoyl) (sodium)
UNSPSC
12352211
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phosphatidylinositol-1-2-dioctanoyl-sodium.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCC(OC[C@@H](OC(CCCCCCC)=O)COP(O[C@H]1[C@@H]([C@H]([C@@H]([C@H]([C@H]1O)O)O)O)O)(O[Na])=O)=O
Molecular Formula
C25H46NaO13P
Molecular Weight
608.59
References & Citations
[1]Lucas X, et al. Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies. PLoS One. 2013 Apr 9;8 (4) :e60679. |[2]Lucas X, et al. Discovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studies. PLoS One. 2013 Apr 9;8 (4) :e60679.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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