Lucidenic lactone

Lucidenic lactone is a terpene compound, is a DNA polymerase inhibitor. Lucidenic lactone inhibits calf DNA polymerase-α, rat DNA polymerase-β, and HIV-1 reverse transcriptase with IC50 values of 42 μM, 99 μM, and 69 μM, respectively[1].

Product Specifications

CAS Number

[250643-34-6]

UNSPSC

12352211

Target

DNA/RNA Synthesis; HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lucidenic-lactone.html

Smiles

C[C@@]12[C@](C3=C([C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])C[C@@H]3O)C)C(C1)=O)([C@H](C[C@@H]2C5(CCC(O5)=O)CO)O)C

Molecular Formula

C27H40O7

Molecular Weight

476.60

References & Citations

[1]Mizushina Y, et al. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. Bioorg Med Chem. 1999 Sep;7 (9) :2047-52.