UK122
Product Specifications
UNSPSC Description
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC50>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion[1].
Target Antigen
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/uk122.html
Purity
99.72
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
N=C(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)N
Molecular Weight
291.30
References & Citations
[1]Ming Zhu, et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol Cancer Ther. 2007 Apr;6(4):1348-56.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111056/UK122-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111056/UK122-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
940290-58-4
Available Sizes
Curated Selection
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