FEN1-IN-1

FEN1-IN-1 (compound 1) is a small molecule flap endonuclease 1 (FEN1) inhibitor with antitumor activity. FEN1-IN-1 binds to the active site of FEN1 and partly achieves inhibition by the co-ordination of Mg2+ ions. FEN1-IN-1 initiaties a DNA damage response and activates the ATM checkpoint signalling pathway, the phosphorylation of histone H2AX and the ubiquitination of FANCD2 in mammalian cells. FEN1-IN-1 is promising for research of cancers[1].

Product Specifications

CAS Number

[824983-91-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ATM/ATR; FLAP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fen1-in-1.html

Purity

99.85

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1N(CC2OC3=CC=CC=C3OC2)C(C=CS4)=C4C(N1O)=O

Molecular Formula

C15H12N2O5S

Molecular Weight

332.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Ward TA, et al. Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One. 2017 Jun 19;12 (6) :e0179278.