LM11

LM11 is an inhibitor of transglutaminase 2 (TG2) with an activity of killing glioblastoma cells by maintaining TG2 in a cytotoxic conformational state[1].

Product Specifications

UNSPSC

12352005

Target

Glutaminase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lm11.html

Solubility

10 mM in DMSO

Smiles

O=C1NC(N(C(/C1=C/NC2=CC(CN3C(C4=C(C3=O)CCC=C4)=O)=C(C=C2)Cl)=O)C5=CC=CC(Cl)=C5)=O

Molecular Formula

C26H18Cl2N4O5

Molecular Weight

537.35

References & Citations

[1]Cody Aplin, et al. Defining the conformational states that enable transglutaminase 2 to promote cancer cell survival versus cell death. bioRxiv. 2024.|[2]Sabrina Schlienger, et al. ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions. Cell Signal. 2015, 27, 3.