6,7-Dihydroxy-4-coumarinylacetic acid
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].
Product Specifications
CAS Number
[88404-14-2]
UNSPSC
12171500
Hazard Statement
H315-H319-H335
Target
Aldose Reductase
Type
Dye Reagents
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/6-7-dihydroxy-4-coumarinylacetic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CC(C1=CC(O)=C(O)C=C1O2)=CC2=O
Molecular Formula
C11H8O6
Molecular Weight
236.18
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kato A, et al. 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20 (19) :5630-3.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
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