6,7-Dihydroxy-4-coumarinylacetic acid

6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].

Product Specifications

CAS Number

[88404-14-2]

UNSPSC

12171500

Hazard Statement

H315-H319-H335

Target

Aldose Reductase

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/6-7-dihydroxy-4-coumarinylacetic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(O)CC(C1=CC(O)=C(O)C=C1O2)=CC2=O

Molecular Formula

C11H8O6

Molecular Weight

236.18

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kato A, et al. 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20 (19) :5630-3.

Shipping Conditions

Room temperature

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Curated Selection

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