6,7-Dihydroxy-4-coumarinylacetic acid
Product Specifications
UNSPSC Description
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation[1].
Target Antigen
Aldose Reductase
Type
Dye Reagents
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/6-7-dihydroxy-4-coumarinylacetic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CC(C1=CC(O)=C(O)C=C1O2)=CC2=O
Molecular Weight
236.18
References & Citations
[1]Kato A, et al. 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5630-3.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-D0064/6-7-Dihydroxy-4-coumarinylacetic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-D0064/
Clinical Information
No Development Reported
CAS Number
88404-14-2
Curated Selection
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