Semicarbazide (hydrochloride)

Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO) . Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles[1][2][3][4][5][6][7][8][9].

Product Specifications

CAS Number

[563-41-7]

Product Name Alternative

Aminourea (hydrochloride) ; Hydrazinecarboxamide (hydrochloride)

UNSPSC

12352211

Hazard Statement

H301, H314, H361, H373, H402

Target

Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Endocrinology; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/semicarbazide-hydrochloride.html

Purity

99.5

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

NNC(N)=O.[H]Cl

Molecular Formula

CH6ClN3O

Molecular Weight

111.53

Precautions

H301, H314, H361, H373, H402

References & Citations

[1]Adam Becalski, et al. Semicarbazide Formation in Azodicarbonamide-Treated Flour: A Model Study. J Agric Food Chem. 2004 Sep 8;52 (18) :5730-4.|[2]Hernandez M, et al. Soluble semicarbazide sensitive amine oxidase (SSAO) catalysis induces apoptosis in vascular smooth muscle cells. Biochim Biophys Acta. 2006 Feb;1763 (2) :164-73.|[3]Takahashi M, et al. Chronic toxicity and carcinogenicity of semicarbazide hydrochloride in Wistar Hannover GALAS rats. Food Chem Toxicol. 2014 Nov;73:84-94.|[4]Takahashi M, et al. Age-related susceptibility to induction of osteochondral and vascular lesions by semicarbazide hydrochloride in rats. Toxicol Pathol. 2010 Jun;38 (4) :598-605.|[5]Elswaidy N R, et al. The effect of semicarbazide on the thyroid gland of juvenile male albino rat and possibility of recovery: Histological and immunohistochemical study. Egyptian Journal of Histology, 2022, 45 (2) : 537-547.|[6]Alazouny Z M, et al. Harmful Effect of Semicarbazide on the Ovary of Adult Albino Rats and the Possible Reversibility of the Induced Lesions (Biochemical and Histological Study) . Egyptian Journal of Histology, 2023, 46 (2) : 810-821.|[7]Mansour A M, et al. Histological Study of the Effect of Semicarbazide on Testicular Seminiferous Tubules of Juvenile Albino Rat. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2018, 30 (1) : 27-37.|[8]Maranghi F, et al. Effects of the food contaminant semicarbazide following oral administration in juvenile Sprague-Dawley rats. Food Chem Toxicol. 2009 Feb;47 (2) :472-9.|[9]Huang H Y, et al. Study on semicarbazide-induced oxidative stress and hepatic metabolic damage in SD rats. 2021.