Ac-ANW-AMC

Ac-ANW-AMC is a fluorogenic substrate for immunoproteasome. Ac-ANW-AMC can be used to measure β5i activity (Ex=345 nm, Em=445 nm) [1][2].

Product Specifications

CAS Number

[2357123-49-8]

UNSPSC

12171500

Target

Proteasome

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-anw-amc.html

Purity

99.40

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1OC2=CC=C(C=C2C(C)=C1)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](C)NC(C)=O)=O)=O)CC3=CNC4=CC=CC=C34)=O

Molecular Formula

C30H32N6O7

Molecular Weight

588.61

References & Citations

[1]Winter, M.B., La Greca, F., Arastu-Kapur, S., et al. Immunoproteasome functions explained by divergence in cleavage specificity and regulation. eLife 6:e27364, (2017) . |[2]Sumin Kim, et al. Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates. Immune Netw. 2022 Apr 15;22 (3) :e28.