Human CLEC5A / MDL-1 Protein, His Tag, active dimer (MALS & SPR verified)
Human CLEC5A, His Tag (CLA-H5243) is expressed from human 293 cells (HEK293) . It contains AA Pro 28 - Lys 188 (Accession # Q9NY25-1) .
Product Specifications
Background
CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.CLEC5A is expressed on monocytes, macrophages, and neutrophils. Its expression is up-regulated on monocytes in rheumatoid arthritis. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.
Specifications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 39.0 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
Q9NY25-1
Expression Region
Pro 28 - Lys 188
Host
HEK293
Target
CLEC5A
Conjugation
Unconjugated
Tag
N-10xHis
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
95%
Format
Powder
Buffer
PBS, pH7.4
Additives
Trehalose
Molecular Weight
39.0 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CLA-H5243.pdf
Species
Human
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