TPP-1
TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM) . TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function[1].
Product Specifications
CAS Number
2426685-25-6
UNSPSC
12352209
Target
PD-1/PD-L1
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tpp-1.html
Purity
99.13
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CO)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CS)NC([C@@H](NC([C@H](CS)NC([C@@H](NC([C@@H](NC([C@H](CO)NC([C@H](C)NC([C@@H](NC([C@H](CCC(N)=O)NC(CNC([C@@H](N)CO)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)CC4=CN=CN4)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O
Molecular Formula
C107H150N34O32S2
Molecular Weight
2488.67
References & Citations
[1]Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6 (2) :178-188.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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