TPP-1
TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM) . TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function[1].
Product Specifications
CAS Number
2426685-25-6
UNSPSC
12352209
Target
PD-1/PD-L1
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tpp-1.html
Purity
99.13
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CO)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CS)NC([C@@H](NC([C@H](CS)NC([C@@H](NC([C@@H](NC([C@H](CO)NC([C@H](C)NC([C@@H](NC([C@H](CCC(N)=O)NC(CNC([C@@H](N)CO)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)CC4=CN=CN4)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)CC7=CNC8=CC=CC=C78)=O)=O
Molecular Formula
C107H150N34O32S2
Molecular Weight
2488.67
References & Citations
[1]Chunlin Li, et al. Peptide Blocking of PD-1/PD-L1 Interaction for Cancer Immunotherapy. Cancer Immunol Res. 2018 Feb;6 (2) :178-188.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
124832-APC 100 µL
CEBPG (CCAAT/Enhancer-binding Protein gamma, C/EBP gamma) (APC)
Sign In for Pricing
View Details