BB2-50F

BB2-50F is an antimicrobial agent and succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F induces ROS. BB2-50F inhibits succinate oxidation and reduces tricarboxylic acid (TCA) cycle activity. BB2-50F inhibits the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic, attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with an MIC of 8 μM[1].

Product Specifications

CAS Number

[2226086-65-1]

UNSPSC

12352005

Target

Bacterial; Reactive Oxygen Species (ROS) ; Succinate Dehydrogenase

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bb2-50f.html

Purity

99.52

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC(N)=N)C1=NC(C2=CC3=C(O2)C=CC=C3)=C(N4CCCCCC4)N=C1N

Molecular Formula

C20H23N7O2

Molecular Weight

393.44

References & Citations

[1]Adolph C, et al. A dual-targeting succinate dehydrogenase and F1Fo-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis. Cell Chem Biol. 2023 Dec 21:S2451-9456 (23) 00432-4.