3-Sulfo-taurocholic Acid Disodium Salt

3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.

Product Specifications

CAS Number

[71781-33-4]

Product Name Alternative

3-Sulfocholyl Taurine; TCA3S

UNSPSC

12352211

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-sulfo-taurocholic-acid-disodium-salt.html

Purity

99.9

Smiles

O=C(NCCS(=O)(O[Na])=O)CC[C@@H](C)[C@](CC1)([H])[C@]2(C)[C@]1([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])C[C@@H]2O

Molecular Formula

C26H43NNa2O10S2

Molecular Weight

639.73

References & Citations

[1]Li, et al. Sortilin 1 loss-of-function protects against cholestatic liver injury by attenuating hepatic bile acid accumulation in bile duct ligated mice. Toxicol. Sci. 161 (1), 34-47 (2018) .